کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162261 | 1114324 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Performance of Pressurized MeteredâDose Inhalers at Extreme Temperature Conditions
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The performance of pressurized meteredâdose inhalers (pMDIs) under a variety of temperature conditions was investigated. The effects of both inhaler temperature and ambient temperature were considered. The inhaler temperature ranged from â13.0°C to 41.7°C and the ambient temperature ranged from â12.0°C to 41.7°C. The in vitro lung dose was measured for four widely available pMDIs: AiromirTM, QVARTM, Symbicort®, and Ventolin®. The in vitro lung dose through an Alberta Idealized Throat was measured by gravimetric assay, which was verified by UV spectroscopic assay. A decrease in the in vitro lung dose was observed for all evaluated pMDIs when ambient temperature and device temperature were simultaneously reduced, decreasing on average by 70% at the coldest temperatures, whereas increasing on average by 25% at the elevated temperature condition. In vitro lung dose is strongly dependent on both inhaler temperature and ambient temperature with the tested pMDIs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3553-3559
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3553-3559
نویسندگان
Chelsea M.D. Morin, James W. Ivey, Jordan T.F. Titosky, Jonathan D. Suderman, Jason S. Olfert, Reinhard Vehring, Warren H. Finlay,