کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162381 | 1114328 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Loading and Release of Amine Drugs by Ion-Exchange Fibers: Role of Amine Type
ترجمه فارسی عنوان
بارگذاری و انتشار مواد آمین با استفاده از الیاف یون تبادل: نقش نوع آمین
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کلمات کلیدی
حامل مواد مخدر پلیمری، خواص فیزیکوشیمیایی، سینتیک، مدل ریاضی، آزادی کنترل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
With more production and application of ion-exchange fibers (IEFs), it becomes necessary to understand the interaction between IEFs and amine compounds, an important group of organic drugs and structural components of large organic molecules in biological systems. However, so far few experimental studies have been conducted to systematically investigate the exchanging mechanism of amine compounds to IEFs. Therefore, 15 amine drugs were selected to investigate the effect of amine type on the loading and release of them from the related IEFs. Loading affinity of these drugs by IEFs decreased in the order of secondary, tertiary, and primary. The following items: basicity, aromaticity, molar volume, rotatability, and so on, were emphatically discussed to address the underlying mechanism of drug loading and releasing extent and rate of IEFs. It was evident that strong alkaline drugs strengthened the ionic bond between the amine groups and IEFs, and thus the loading affinity. These results will advance the understanding of the exchanging behavior of IEFs in the drug delivery system. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1095-1103, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1095-1103
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1095-1103
نویسندگان
Yanan Gao, Hongzhuo Liu, Jing Yuan, Yang Yang, Xin Che, Yanlong Hou, Sanming Li,