کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162469 | 1114330 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbon Monoxide-Bound Red Blood Cell Resuscitation Ameliorates Hepatic Injury Induced by Massive Hemorrhage and Red Blood Cell Resuscitation via Hepatic Cytochrome P450 Protection in Hemorrhagic Shock Rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NOx, nitrogen oxideCO, carbon monoxide - CO، مونوکسید کربنMDA, malondialdehyde - MDA، مالون دی آلدئیدRBC, red blood cells - RBC، گلبول های قرمزROS, Reactive Oxygen Species - ROS، انواع اکسیژن واکنشیAST, aspartate aminotransferase - آزمایش آسپارتات آمینوترانسفرازALT, alanine aminotransferase - آلانین آمینوترانسفرازDrug effects - اثرات مواد مخدرDrug transport - حمل مواد مخدرCYP, cytochrome P450 - سیتوکروم P450Cytochrome P450 - سیتوکروم پی۴۵۰Pharmacokinetics - فارماکوکینتیکHepatic metabolism - متابولیسم کبدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Red blood cell (RBC) transfusions are the gold standard in cases of massive hemorrhage, but induce hepatic ischemia-reperfusion injury, a serious complication associated with hemorrhage and RBC resuscitation. Thus, the development of a novel resuscitable fluid that is not associated with hepatic ischemia-reperfusion injury would be desirable. It was reported that exogenous carbon monoxide (CO) treatment ameliorated hepatic ischemia-reperfusion injury accompanying liver transplantation. This suggests that transfusions with CO-bound RBC (CO-RBC) might protect against hepatic ischemia-reperfusion injury following massive hemorrhage and resuscitation compared with RBC resuscitation. To investigate this, we created a hemorrhagic shock model rat, followed by resuscitation with RBC and CO-RBC. Hepatic ischemia-reperfusion injury and the destruction of hepatic cytochrome P450 (CYP) were significantly ameliorated in the CO-RBC resuscitation group compared with the RBC resuscitation group. The free heme derived from the destruction of hepatic CYP was correlated with hepatic oxidation and injury, suggesting that CO-RBC was a major factor in the amelioration of hepatic ischemia-reperfusion injury induced by hemorrhage and resuscitation via hepatic CYP protection. These results indicate that CO-RBC has potential for use as a resuscitative fluid in blood transfusion and does not suffer from the limitations associated with the RBC transfusions that are currently in use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 7, July 2014, Pages 2199-2206
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 7, July 2014, Pages 2199-2206
نویسندگان
Shigeru Ogaki, Kazuaki Taguchi, Hiroshi Watanabe, Yu Ishima, Masaki Otagiri, Toru Maruyama,