کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10212250 | 1671350 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long term prognosis of Scheuermann's disease: The association with fragility fracture - The MINOS cohort
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کلمات کلیدی
Scheuermann's diseaseSCDAACBMDRIADXA25OHDINSERMALMBone mineral density - تراکم معدنی استخوانappendicular lean mass - توده لاغر آپاندیکلیDual x-ray absorptiometry - دوز جذبی سنجی اشعه ایکسradioimmunoassay - رادیوایمونواسیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیVertebral fracture - شکستگی مهرهCoefficient of Variation - ضریب تغییرOlder men - مردان مسن ترInstitut National de la Santé et de la Recherche Médicale - موسسه ملی بهداشت و تحقیقات پزشکی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
The aim was to assess the association of Scheuermann's disease (SCD) with fracture risk (vertebral, peripheral) and bone mineral density (BMD) in older men. SCD was assessed on the baseline lateral spine radiographs using the Berlin criteria in 766 men aged 50-85. We evaluated the association of SCD and its diagnostic criteria with incident fracture (vertebral over 7.5â¯years, peripheral over 10â¯years) and BMD (baseline). SCD prevalence was 25.2%. SCD and its criteria showed inconsistent associations with BMD at different skeletal sites. Eighty-four men had incident fractures. After adjustment for age, weight, spine BMD, prevalent vertebral fractures, prior falls and score of disc space narrowing due to osteoarthritis (DSN-OA), SCD was not associated with vertebral fracture risk. Vertebral endplate irregularities (EI), one of its diagnostic criteria, were associated with higher vertebral fracture risk (ORâ¯=â¯3.26, 95% CI: 1.34-7.94, pâ¯<â¯0.01). Vertebral fracture risk was higher in men with EI and low spine BMD vs. men without these characteristics (ORâ¯=â¯12.84, 95% CI: 3.12-52.83, pâ¯<â¯0.005). EI was associated with higher vertebral fracture risk in men without severe DSN-OA and without prevalent vertebral fractures. Peripheral fracture risk was lower in men with SCD (HRâ¯=â¯0.39, 95% CI: 0.18-0.83, pâ¯<â¯0.02) and EI. Peripheral fracture risk was higher in men without SCD who had low femoral neck BMD vs. men with SCD and normal BMD (HRâ¯=â¯4.68, 95% CI: 1.09-20.03, pâ¯<â¯0.05). In conclusion, EI were associated with high vertebral fracture risk. SCD and EI were associated with lower peripheral fracture risk. The associations of SCD and its criteria with BMD were inconsistent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 117, December 2018, Pages 116-122
Journal: Bone - Volume 117, December 2018, Pages 116-122
نویسندگان
Marine Gaudé, Roland Chapurlat, Jean-Baptiste Pialat, Pawel Szulc,