کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10265786 | 458647 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dissecting the puzzle of life: modularization of signal transduction networks
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dissecting the puzzle of life: modularization of signal transduction networks Dissecting the puzzle of life: modularization of signal transduction networks](/preview/png/10265786.png)
چکیده انگلیسی
Cells have developed complex control networks which allow them to sense and response to changes in their environment. Although they have different underlying biochemical mechanisms, signal transduction units in prokaryotes and eukaryotes fulfill similar tasks, such as switching on or off a required process or amplifying a certain signal. The growing amount of data available allows the development of increasingly complex models which offer a detailed picture of signaling networks, but the properties of these systems as a whole become difficult to grasp. A sound strategy to untangle this complexity is a decomposition into smaller units or modules. How modules should be delimited, however, remains an unanswered question. We propose that units without retroactive effects might be an interesting criterion. In this contribution, this issue will be explored through several examples, starting with a simple two-component system in Escherichia coli up to the complex epidermal growth factor signaling pathway in human cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 29, Issue 3, 15 February 2005, Pages 619-629
Journal: Computers & Chemical Engineering - Volume 29, Issue 3, 15 February 2005, Pages 619-629
نویسندگان
J. Saez-Rodriguez, A. Kremling, E.D. Gilles,