Coupling fluid flow, heat transfer and thermal denaturation-aggregation of beta-lactoglobulin using an Eulerian/Lagrangian approach

► We study beta-lactoglobulin aggregation during continuous thermal treatment. ► Aggregation is estimated along Lagrangian trajectories using sizes class method. ► Transformation is coupled with fluid flow and heat transfer classically estimated. ► Thermal and shear rate histories along the domain drive the aggregation magnitude. ► Obtained particle sizes distribution shows product diversity unlike 1D model.