کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10308152 548136 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms
چکیده انگلیسی
Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n=335) from north India. Tardive dyskinesia was diagnosed in ∼29% (96/335) of these patients. No significant association of either of the two SNPs with TD (CYP3A4*1B χ2=0. 308, df=1, p=0.579; CYP2D6*4 χ2=0.006, df=1, p=0.935) was observed. However a trend towards increased severity of TD in patients heterozygous for the CYP2D6*4 mutation was observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 75, Issue 1, 1 June 2005, Pages 21-26
نویسندگان
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