Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation

► Impact of anaerobiosis strategy on 1,3-propanediol production by Clostridium butyricum. ► Investigation of 1,3-propanediol production in bioreactors with different geometry. ► Extensive discussion of the biochemical diversions observed. ► High production of 1,3-propanediol in optimized fed-batch bioreactor culture.