Strain rate influences periosteal adaptation in mature bone

Furthermore, a graded dose-response relation was observed between the applied strain rate and periosteal BFR BS−1. These increases in MAR, MS, and BFR BS−1 were not seen on the endosteal surface. Endosteal adaptation was not statistically different between loaded and control tibiae in most endosteal indices of bone adaptation. Moreover, endosteal adaptation did not increase with strain rate. Understanding the nature of the stimuli to which bone cells respond to may underpin the development of non-pharmacological treatments devised to enhance bone mass.