Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells

Nanoparticle surface charge is a key parameter in the recruitment and association of pulmonary antigen presenting cells following respiratory administration, resulting in increased cytokine and chemokine production necessary for an effective lung vaccine. Pulmonary delivery of PRINT® cationic nanoparticles resulted in an increased local immune response and preferential association with dendritic cells compared to PRINT® anionic nanoparticle administration.200