کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10450003 | 918343 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence for efficacy of acute treatment of episodic tension-type headache: Methodological critique of randomised trials for oral treatments
ترجمه فارسی عنوان
شواهد برای اثربخشی درمان حاد سردرد تنش اپیزودیک: نقد متدولوژیک از آزمایشات تصادفی برای درمان خوراکی
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The International Headache Society (IHS) provides guidance on the conduct of trials for acute treatment of episodic tension-type headache (TTH), a common disorder with considerable disability. Electronic and other searches identified randomised, double-blind trials of oral drugs treating episodic TTH with moderate or severe pain at baseline, or that tested drugs at first pain onset. The aims were to review methods, quality, and outcomes reported (in particular the IHS-recommended primary efficacy parameter pain-free after 2Â hours), and to assess efficacy by meta-analysis. We identified 58 reports: 55 from previous reviews and searches, 2 unpublished reports, and 1 clinical trial report with results. We included 40 reports of 55 randomised trials involving 12,143 patients. Reporting quality was generally good, with potential risk of bias from incomplete outcome reporting and small size; the 23 largest trials involved 82% of patients. Few trials reported IHS outcomes. The number needed to treat values for being pain-free at 2Â hours compared with placebo were 8.7 (95% confidence interval [CI] 6.2 to 15) for paracetamol 1000Â mg, 8.9 (95% CI 5.9 to 18) for ibuprofen 400Â mg, and 9.8 (95% CI 5.1 to 146) for ketoprofen 25Â mg. Lower (better) number needed to treat values were calculated for outcomes of mild or no pain at 2Â hours, and patient global assessment. These were similar to values for these drugs in migraine. No other drugs had evaluable results for these patient-centred outcomes. There was no evidence that any one outcome was better than others. The evidence available for treatment efficacy is small in comparison to the size of the clinical problem.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN® - Volume 155, Issue 11, November 2014, Pages 2220-2228
Journal: PAIN® - Volume 155, Issue 11, November 2014, Pages 2220-2228
نویسندگان
R. Andrew Moore, Sheena Derry, Philip J. Wiffen, Sebastian Straube, Lars Bendtsen,