کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10450315 | 918354 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Shared genetic factors underlie chronic pain syndromes
ترجمه فارسی عنوان
عوامل ژنتیکی به اشتراک گذاشته شده مبتنی بر سندرم درد مزمن هستند
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کلمات کلیدی
سندرم درد مزمن، درد گسترده مزمن، بیماری چشم خشک، محیط، سندرم سوپرفون عملکردی، ژن، وراثت، سندرم روده تحریک پذیر، میگرن، درد، درد لگن،
Dry eye disease - بیماری چشم خشکPain - دردPelvic pain - درد لگنChronic widespread pain - درد گسترده مزمنChronic pain syndrome - سندرم درد مزمنFunctional somatic syndrome - سندرم سوپرفون کارکردیirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیEnvironment - محیط زیستMigraine - میگرنHeritability - وراثت پذیریGene - ژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Chronic pain syndromes (CPS) are highly prevalent in the general population, and increasingly the evidence points to a common etiological pathway. Using a large cohort of twins (n = 8564) characterized for chronic widespread musculoskeletal pain (CWP), chronic pelvic pain (PP), migraine (MIG), dry eye disease, and irritable bowel syndrome (IBS), we explored the underlying genetic and environmental factors contributing to CPS and the correlation between them. The sample was predominantly female (87.3%), with a mean age of 54.7 (±14.7) years. Prevalence of the different CPS ranged from 7.4% (PP) to 15.7% (MIG). For all CPS the within-twin correlation in monozygotic twin pairs was higher than in dizygotic pairs, suggesting a heritable component. Estimated heritability ranged from 19% (IBS) to 46% (PP). Except for MIG, we found significant pairwise phenotypic correlations between the CPS. The phenotypic correlation was highest between CWP and IBS (0.40; 95% confidence interval: 0.27 to 0.46). Excluding MIG from further analyses, cross-twin cross-trait correlations were higher in monozygotic compared with dizygotic twin pairs, suggestive of shared genetic factors between CWP, PP, IBS, and dry eye disease. Twin modeling analysis revealed the common pathway model as the model best explaining the observed pattern of correlation between the traits, with an estimated heritability of 66% of the underlying latent variable. These results are evidence of shared genetic factors in conditions manifesting chronic pain and justify the search for underlying genetic variants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN® - Volume 155, Issue 8, August 2014, Pages 1562-1568
Journal: PAIN® - Volume 155, Issue 8, August 2014, Pages 1562-1568
نویسندگان
Jelle Vehof, Helena M.S. Zavos, Genevieve Lachance, Christopher J. Hammond, Frances M.K. Williams,