کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10451150 | 918391 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Persistent ictal-like visual cortical excitability in chronic migraine
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کلمات کلیدی
ECDMIDASDNICMSPAVEFTMSmigraine disability assessment - ارزیابی ناتوانی میگرنMEG - بهTranscranial magnetic stimulation - تحریک مغناطیسی مغزequivalent current dipole - دو قطبی معادل فعلیmagnetoencephalography - مغناطیس مغزEpisodic migraine - میگرن اپیزودیکChronic migraine - میگرن مزمنDiffuse noxious inhibitory control - کنترل مهار کننده های مضر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Episodic migraine (EM) may evolve into the more disabling chronic migraine (CM, monthly migraine days ⩾ 8 and headache days ⩾ 15) with unknown mechanism. Aiming to elucidate the pathophysiology of CM and its relationship with EM, this study characterized the visual cortical responses in CM and EM. Neuromagnetic visual-evoked responses to left-hemifield checkerboard reversals were obtained in patients with EM (interictal or ictal states), CM (interictal) and age-matched controls. For each subject, the 1500 evoked responses were sequentially divided into 30 blocks and percentage changes of P100m amplitude in blocks 2, 9, 16, 23, and 30 compared to the first block were computed to assess habituation. At the end of visual stimulation (block 30), P100m amplitude was decreased (habituated) in the controls (n = 32) (35.2 ± 2.6 nAm vs. 41.9 ± 2.7, p = 0.005) but increased (potentiated) in the interictal state of EM (n = 29) (39.7 ± 3.8 vs. 33.5 ± 3.0, p = 0.007). In CM (n = 25), P100m was habituated (46.5 ± 2.9 vs. 51.6 ± 3.7, p = 0.013) but higher at the initial block than in those of the interictal state of EM (p = 0.001). These CM features also characterized the P100m in the ictal state of EM (n = 9). There was no difference of P100m between CM and ictal state of EM. In conclusion, patients with CM demonstrate a persistent ictal-like excitability pattern of the visual cortex between migraine attacks which may implicate central inhibitory dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN® - Volume 152, Issue 2, February 2011, Pages 254-258
Journal: PAIN® - Volume 152, Issue 2, February 2011, Pages 254-258
نویسندگان
Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin,