The endocannabinoid anandamide downregulates IL-23 and IL-12 subunits in a viral model of multiple sclerosis: Evidence for a cross-talk between IL-12p70/IL-23 axis and IL-10 in microglial cells

► Anandamide downregulates IL-12p70 and IL-23 in TMEV-IDD influencing adaptive immunity. ► TMEV-infected microglia is a target for anandamide actions. ► Decreased IL-12p70 and IL-23 by anandamide involves IL-10 upregulation in microglia. ► Importance of CB2 and ERK1/2 and JNK phosphorylation in anandamide cytokine effects.