کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10529529 | 960810 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Collaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A collaborative study applying an enantiomeric liquid chromatographic (LC) method was carried out to determine the content of the enantiomeric impurity R-timolol and other related substances in three different S-timolol maleate samples. Eight laboratories, all located in Europe, participated in the study. The quantitative results obtained were used to estimate the uncertainty on the content of the different impurities. For that purpose, a set-up was adapted from the ISO guidelines 5725-2, which allowed the estimation of the different variances, i.e. the between-laboratories (slaboratories2), the between-days (sdays2) and the between-replicates (sreplicates2). The variances of repeatability (sr2) and reproducibility (sR2) were then calculated using the equations sr2=sreplicates2 and sR2=sreplicates2+sdays2+slaboratories2. For the timolol impurities, it was found that the estimated uncertainty seem to be concentration-dependent. Since the LC method which combines the compendial ones for enantiomeric purity and related substances testing was applied to evaluate uncertainty in this collaborative study, it was shown how a laboratory can evaluate the uncertainty of its results when applying the method in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 546, Issue 2, 8 August 2005, Pages 182-192
Journal: Analytica Chimica Acta - Volume 546, Issue 2, 8 August 2005, Pages 182-192
نویسندگان
R.D. Marini, N. Matthijs, Y. Vander Heyden, J. Smeyers-Verbeke, P. Dehouck, J. Hoogmartens, P. Silvestre, A. Ceccato, Ph. Goedert, J. Saevels, C. Herbots, G. Caliaro, R. Herráez-Hernández, J. Verdú-Andrès, P. CampÃns-falcó, W. Van de Wauw,