Inhibition of the formation of advanced glycation end products by thymoquinone

► Advanced glycation end products (AGEs) are associated with the development of chronic degenerative diseases including obesity, diabetes, Alzheimer's, cardiovascular, and cancer. ► The efficacy of thymoquinone, against the formation of AGEs was investigated. ► Thymoquinone at concentration that is not toxic to normal cells inhibited the formation of early and late glycation of human serum albumin ex vivo. ► The potential of thymoquinone is the prevention of the development of human chronic diseases is discussed.