کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553314 | 967726 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Single-strain starter experimental cheese reveals anti-inflammatory effect of Propionibacterium freudenreichii CIRM BIA 129 in TNBS-colitis model
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کلمات کلیدی
CFUDSSGRASIBDTNBSSurfaceomeTrinitrobenzene sulphonic acid - اسید سولفونی ترنیتروبنزنColitis - التهاب روده بزرگgenerally recognized as safe - به طور کلی به عنوان امن شناخته شده استinflammatory bowel diseases - بیماری های روده ای التهابیCrohn's disease - بیماری کرونdextran sodium sulphate - سولفات سدیم سدیمcolony-forming unit - واحد تشکیل کلنیProbiotic cheese - پنیر پروبیوتیکUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Single-strain starter experimental cheese reveals anti-inflammatory effect of Propionibacterium freudenreichii CIRM BIA 129 in TNBS-colitis model Single-strain starter experimental cheese reveals anti-inflammatory effect of Propionibacterium freudenreichii CIRM BIA 129 in TNBS-colitis model](/preview/png/10553314.png)
چکیده انگلیسی
Propionibacterium freudenreichii is a beneficial bacterium consumed as a cheese starter and as a probiotic. It displays promising immunomodulatory properties and selected strains exert an anti-inflammatory effect via key surface proteins. Cheese constitutes an important source of bacteria, which can have beneficial effects, depending on the species or strain. We developed here a single-strain experimental pressed cheese, exclusively fermented by P.âfreudenreichii, in order to investigate its health effects, which is not possible in a complex cheese ecosystem. Key immunomodulatory surface proteins were expressed within the cheese matrix. Consumption of this axenic cheese protected mice from acute colitis induced by TNBS (trinitrobenzenesulphonic acid). Induction of local and systemic inflammatory markers, as well as colon epithelial oxidative stress markers, was prevented. This work confirms the probiotic potential of P. freudenreichii and provides a new functional fermented product for preclinical and clinical studies aimed at prevention or treatment of IBD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 575-585
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 575-585
نویسندگان
Coline Plé, Romain Richoux, Julien Jardin, Marine Nurdin, Valérie Briard-Bion, Sandrine Parayre, Stéphanie Ferreira, Bruno Pot, Guillaume Bouguen, Stéphanie-Marie Deutsch, Hélène Falentin, Benoit Foligné, Gwénaël Jan,