Pt(II) complexes with (N,N′) or (C,N,E)− (E = N,S) ligands: Cytotoxic studies, effect on DNA tertiary structure and structure-activity relationships

- Cytotoxic evaluation of Pt(II) complexes with (N,N′) or (C,N,E)− (E = N,S) ligands.
- Remarkable antiproliferative activity in lung, breast and colon human cancer cells.
- These compounds modify the DNA tertiary structure, in a similar way as cisplatin.
- Structure-activity relationship and theoretical calculations analysis.