Benzo[b]thiophene-6-carboxamide 1,1-dioxides: Inhibitors of human cancer cell growth at nanomolar concentrations

New BTC showed nM GI50 against HTB-54, CCRF-CEM and HeLa and sub-μM against K-562, MEL-AC and HT-29 tumour cell lines. BTC induced apoptosis in CCRF-CEM and a significant increase in the rate of intracellular ROS generation.