Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis

Four commercial available furocoumarin derivatives were selected from VS studies of a focus library against NF-κB for further biological evaluation. Three of the identified molecules (6f, 7f and 9f) significantly inhibited NF-κB dependent biological functions and might be of interest for experimental therapy of cystic fibrosis.