کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10602350 | 982374 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends](/preview/png/10602350.png)
چکیده انگلیسی
Both 5-fluorouracil (5-FU) and leucovorin (LV) are hydrophilic drugs which are used in combination for the treatment of colon cancer. Chitosan (CS) nanoparticles were prepared by ionic gelation technology, and then used for trapping 5-FU and LV. Combination drugs were encapsulated into CS nanoparticles as a result of electrostatic interactions, which was confirmed by Fourier transform spectroscopy (FTIR). XRD results demonstrated that the both drugs were distributed in the CS nanoparticles in the amorphous state. Efficient encapsulation efficiency (EE) and loading capacity (LC) were achieved which were correlated to their initial drug concentration. Simultaneous release of 5-FU and LV from CS nanoparticles were observed in vitro studies; both 5-FU and LV experienced initial burst release which was followed by a constant and continuous release. The release of drugs was influenced by their initial drug concentration, indicating that the release of drugs could be controlled by varying the initial drug concentration. All results suggested that CS nanoparticles are promising system for simultaneously delivering 5-FU and LV in treatment of colon cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 85, Issue 3, 1 June 2011, Pages 698-704
Journal: Carbohydrate Polymers - Volume 85, Issue 3, 1 June 2011, Pages 698-704
نویسندگان
Puwang Li, Yichao Wang, Zheng Peng, Fenghua She, Lingxue Kong,