کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10609867 984736 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and self-assembly of pH-responsive amphiphilic dendritic star-block terpolymer by the combination of ROP, ATRP and click chemistry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and self-assembly of pH-responsive amphiphilic dendritic star-block terpolymer by the combination of ROP, ATRP and click chemistry
چکیده انگلیسی
Novel pH-responsive amphiphilic dendritic star-block poly(l-lactide)-b-poly(2-(N, N-diethylamino)ethyl methacrylate)-b-poly(ethylene oxide) (DPLLA-b-PDEAEMA-b-PEO) terpolymers were synthesized by the combination of ring-opening polymerization (ROP), atom transfer radical polymerization (ATRP), and click chemistry. DPLLAOH was synthesized by ROP of l-lactide (LLA) and then reacted with propargyl 3-carboxylic-propanoate to obtain alkynyl-DPLLA. PEO-b-PDEAEMA-Br was prepared by ATRP of DEAEMA and then reacted with NaN3 to obtain PEO-b-PDEAEMA-N3. DPLLA-b-PDEAEMA-b-PEO was easily prepared by click chemistry of alkynyl-DPLLA and PEO-b-PDEAEMA-N3. DPLLA-b-PDEAEMA-b-PEO can assemble into micelles in water with PLLA segments as core and PEO segments as corona. The hydrophilicity/hydrophobicity of PDEAEMA can be adjusted with the alteration of pH values. Therefore, PDEAEMA segments form core or corona of micelles at pH ⩾ 7 or pH < 7. Due to the pH-responsive property of PDEAEMA and unique structure of terpolymer, the size and conformation of the micelles can be changed to some extent by altering the pH values of solutions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Polymer Journal - Volume 47, Issue 5, May 2011, Pages 949-958
نویسندگان
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