کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10612679 | 986648 | 2015 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amifostine-conjugated pH-sensitive calcium phosphate-covered magnetic-amphiphilic gelatin nanoparticles for controlled intracellular dual drug release for dual-targeting in HER-2-overexpressing breast cancer
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A co-delivery strategy has been developed to achieve the synergistic effect of hydrophobic drug (CUR) and hydrophilic drug (DOX) by utilizing the unique structure of amphiphilic gelatin. An obvious contrast appeared in the tumor between HER-AGIO@CaP-CD and AGIO@CaP-CD under the IVIS imaging system after one day. Additionally, the aggregation of HER-AGIO@CaP-CD at the tumor site after a long MT may cause the slower release of drug and limit the distribution of drug at the tumor, which further affects the efficacy of the therapy.245
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 220, Part A, 28 December 2015, Pages 107-118
Journal: Journal of Controlled Release - Volume 220, Part A, 28 December 2015, Pages 107-118
نویسندگان
Wei-Ming Li, Chih-Sheng Chiang, Wei-Chen Huang, Chia-Wei Su, Min-Yu Chiang, Jian-Yi Chen, San-Yuan Chen,