کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10691756 | 1019605 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimization of Ultrasound Parameters of Myocardial Cavitation Microlesions for Therapeutic Application
ترجمه فارسی عنوان
بهینه سازی پارامترهای سونوگرافی میکروسلیس های کاویتاسیون میوکارد برای استفاده درمانی
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کلمات کلیدی
اکوکاردیوگرافی کنتراست میوکارد، آریتمی، نکروز مایکوسیت قلب، کاردیومیوپاتی هیپرتروفیک،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
Intermittent high intensity ultrasound scanning with contrast microbubbles can induce scattered cavitation microlesions in the myocardium, which may be of value for tissue reduction therapy. Anesthetized rats were treated in a heated water bath with 1.5 MHz focused ultrasound pulses, guided by an 8 MHz imaging transducer. The relative efficacy with 2 or 4 MPa pulses, 1:4 or 1:8 trigger intervals and 5 or 10 cycle pulses was explored in six groups. Electrocardiogram premature complexes (PCs) induced by the triggered pulse bursts were counted, and Evans blue stained cardiomyocyte scores (SCSs) were obtained. The increase from 2 to 4 MPa produced significant increases in PCs and SCSs and eliminated an anticipated decline in the rate of PC induction with time, which might hinder therapeutic efficacy. Increased intervals and pulse durations did not yield significant increases in the effects. The results suggest that cavitation microlesion production can be refined and potentially lead to a clinically robust therapeutic method.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 6, June 2014, Pages 1228-1236
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 6, June 2014, Pages 1228-1236
نویسندگان
Douglas L. Miller, Chunyan Dou, Gabe E. Owens, Oliver D. Kripfgans,