کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10692483 1019696 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The antivascular action of physiotherapy ultrasound on murine tumors
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
The antivascular action of physiotherapy ultrasound on murine tumors
چکیده انگلیسی
This study was aimed at determining if physiotherapy ultrasound (US) affected the fragile and leaky angiogenic blood vessels in a tumor. In 22 C3HV/HeN mice, a subcutaneous melanoma (K173522) was insonated (1, 2 or 3 min) with continuous 1-MHz low-intensity (spatial-average temporal-average = 2.28 W cm−2), physiotherapy US. Contrast-enhanced (0.1 mL Optison®) power Doppler US observations were made and histogram analyses of the images were performed. Before insonation, all but 7% of the tumor was perfused. The avascular area in tumors receiving 3-min treatment increased to 82% (p < 0.001). A linear regression analysis showed that each min of insonation led to a 25% reduction in tumor vascularity; the antivascular activity persisted for 24 h. Histology demonstrated disruption of vascular walls and tumor cell death in areas of vascular congestion and thrombosis. Physiotherapy US particularly targeted the vascular structures, and the effects on tumor cells appeared to be secondary to the resultant ischemia. (E-mail: sehgalc@uphs.upenn.edu)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 10, October 2005, Pages 1403-1410
نویسندگان
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