کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10736558 | 1045724 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RecQ helicases and PARP1 team up in maintaining genome integrity
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کلمات کلیدی
CPToligonucleotide/oligosaccharide-binding foldRQCRothmund-Thomson syndromePARGARTDHRDCBRCTNLSPARPRTSDSBPBMSSAPBRNHEJBLMSRIBERNER - DOWNOB-fold - OB برابر استHolliday junction - اتصال Hollidaynucleotide excision repair - تعمیر مجدد نوکلئوتیدیbase excision repair - تعمیر پایه پایهPar - توسطBloom syndrome - سندرم بلومnuclear localization signal - سیگنال محلی سازی هسته ایDNA double-strand break - شکست دو رشته DNAnon-homologous end-joining - عدم پیوستن به همولوگHomologous recombination - نوترکیبی همولوگPoly(ADP-ribose) - پلی (ADP-ribose)Poly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازcamptothecin - کامپتوتسین poly(ADP-ribose) glycohydrolase - گلیکا هیدرولاز پلی (ADP-ribose)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Genome instability represents a primary hallmark of aging and cancer. RecQL helicases (i.e., RECQL1, WRN, BLM, RECQL4, RECQL5) as well as poly(ADP-ribose) polymerases (PARPs, in particular PARP1) represent two central quality control systems to preserve genome integrity in mammalian cells. Consistently, both enzymatic families have been linked to mechanisms of aging and carcinogenesis in mice and humans. This is in accordance with clinical and epidemiological findings demonstrating that defects in three RecQL helicases, i.e., WRN, BLM, RECQL4, are related to human progeroid and cancer predisposition syndromes, i.e., Werner, Bloom, and Rothmund Thomson syndrome, respectively. Moreover, PARP1 hypomorphy is associated with a higher risk for certain types of cancer. On a molecular level, RecQL helicases and PARP1 are involved in the control of DNA repair, telomere maintenance, and replicative stress. Notably, over the last decade, it became apparent that all five RecQL helicases physically or functionally interact with PARP1 and/or its enzymatic product poly(ADP-ribose) (PAR). Furthermore, a profound body of evidence revealed that the cooperative function of RECQLs and PARP1 represents an important factor for maintaining genome integrity. In this review, we summarize the status quo of this molecular cooperation and discuss open questions that provide a basis for future studies to dissect the cooperative functions of RecQL helicases and PARP1 in aging and carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 23, Part A, September 2015, Pages 12-28
Journal: Ageing Research Reviews - Volume 23, Part A, September 2015, Pages 12-28
نویسندگان
Sebastian Veith, Aswin Mangerich,