Cellular redox potential and the biomolecular electrochemical series: A systems hypothesis

► Several proteins in the apoptosis pathway are redox regulated. ► Apoptosis is a phenomenon where cellular redox potential becomes more oxidative. ► Redox-regulated proteins could be arranged in an electrochemical series. ► Protein standard oxidation potential correlates with position in the apoptotic pathway. ► Apoptosis could be modeled as a system regulated by cellular redox potential.