کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738404 | 1046704 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function
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کلمات کلیدی
PBSSNCVMDASystemic oxidative stressMNCVPARPDPNSTZ4-HNE4-hydroxynonenalDRGdorsal root ganglion - گانگلیون ریشه پشتیROS - ROSstreptozotocin - استرپتوزوتوسینISO - ایزوFree radicals - رادیکال آزادSensory nerve conduction velocity - سرعت هدایت عصب حسیmotor nerve conduction velocity - سرعت هدایت عصب موتورperipheral nervous system - سیستم عصبی پیرامونیmalondialdehyde - مالون دی آلدهیدPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریPeripheral diabetic neuropathy - نوروپاتی دیابتی محیطیdiabetic peripheral neuropathy - نوروپاتی محیطی دیابتیPoly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازPNS - کارمندان دولتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function](/preview/png/10738404.png)
چکیده انگلیسی
This study evaluated the role of poly(ADP-ribose) polymerase (PARP) in systemic oxidative stress and 4-hydoxynonenal adduct accumulation in diabetic peripheral neuropathy. Control and streptozotocin-diabetic rats were maintained with or without treatment with the PARP inhibitor, 1,5-isoquinolinediol, 3 mg kgâ 1 dayâ 1, for 10 weeks after an initial 2 weeks. Treatment efficacy was evaluated by poly(ADP-ribosyl)ated protein content in peripheral nerve and spinal cord (Western blot analysis) and dorsal root ganglion neurons and nonneuronal cells (fluorescence immunohistochemistry), as well as by indices of peripheral nerve function. Diabetic rats displayed increased urinary isoprostane and 8-hydroxy-2â²-deoxyguanosine excretion (ELISA) and 4-hydroxynonenal adduct accumulation in endothelial and Schwann cells of the peripheral nerve, neurons, astrocytes, and oligodendrocytes of the spinal cord and neurons and glial cells of the dorsal root ganglia (double-label fluorescence immunohistochemistry), as well as motor and sensory nerve conduction velocity deficits, thermal hypoalgesia, and tactile allodynia. PARP inhibition counteracted diabetes-induced systemic oxidative stress and 4-hydroxynonenal adduct accumulation in peripheral nerve and spinal cord (Western blot analysis) and dorsal root ganglion neurons (perikarya, fluorescence immunohistochemistry), which correlated with improvement of large and small nerve fiber function. The findings reveal the important role of PARP activation in systemic oxidative stress and 4-hydroxynonenal adduct accumulation in diabetic peripheral neuropathy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 50, Issue 10, 15 May 2011, Pages 1400-1409
Journal: Free Radical Biology and Medicine - Volume 50, Issue 10, 15 May 2011, Pages 1400-1409
نویسندگان
Sergey Lupachyk, Hanna Shevalye, Yury Maksimchyk, Viktor R. Drel, Irina G. Obrosova,