کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738955 | 1046849 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of aconitase, metallothionein, and oxidative stress in zinc-deficient rat intestine during zinc and iron repletion
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کلمات کلیدی
MDATBA-RSDithiothrietolGSSGGPXDTTTCAGSHBSA - BSAbovine serum albumin - آلبومین سرم گاوIron - آهنaconitase - آکنیتازtrichloroacetic acid - اسید ترشکلراکتیکOxidative stress - تنش اکسیداتیوFree radicals - رادیکال آزادSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازFerritin - فریتینmalondialdehyde - مالون دی آلدهیدMetallothionein - متالوتونیئینthiobarbituric acid-reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکreduced glutathione - کاهش گلوتاتیونZinc deficiency - کمبود رویoxidized glutathione - گلوتاتیون اکسید شدهglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Potential interactions between zinc and iron during absorption and its functional consequences on intestinal oxidative damage and antioxidant status were studied using the zinc-deficient rat as a model. Zinc depletion produced mild-moderate iron deficiency in addition to zinc deficiency, which could be corrected by repletion with iron and zinc. The localization and intensity of both iron and zinc in the intestinal mucosa showed a pronounced decrease in the presence of the other metal, indicating negative interactions. Zinc-deficient intestine exposed to iron alone exhibited elevated peroxidative damage and compromised functional integrity, despite increased expression of ferritin. Inclusion of zinc significantly reduced the damage and improved the functional integrity, accompanied by decreased expression of ferritin. Decreased expression of ferritin in the presence of zinc was consistent with reduced aconitase activity, suggesting its modulation by zinc. Further, inclusion of iron along with zinc was associated with induction of ferritin and metallothionein in tune with the amount of iron and zinc localized in the intestinal mucosa, respectively. These results suggest that zinc and iron interact negatively with cytosolic aconitase, but prove beneficial in reducing the oxidative stress, apart from improving functional integrity and iron/zinc status.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 8, 15 October 2005, Pages 999-1008
Journal: Free Radical Biology and Medicine - Volume 39, Issue 8, 15 October 2005, Pages 999-1008
نویسندگان
Bodiga Sreedhar, Krishnapillai Madhavan Nair,