کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10752804 | 1050332 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner
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کلمات کلیدی
nESPCMCLSMTOCCdc6Centrosome - سانتریفیوژnuclear export signal - سیگنال صادرات هسته ایmicrotubule-organizing center - مرکز میکروتوبولی سازماندهیpericentriolar material - مواد پریکنتریولارmap - نقشهDNA replication - همانندسازی DNA، تکثیر DNAmicrotubule-associated protein - پروتئین مرتبط با میکروتوبولpre-RC - پیش RCPre-replicative complex - پیچیده قبل از تکثیرCell cycle - چرخه سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner](/preview/png/10752804.png)
چکیده انگلیسی
The Cdc6 protein has been primarily investigated as a component of the pre-replicative complex for the initiation of chromosome replication, which contributes to maintenance of chromosomal integrity. Here, we show that Cdc6 localized to the centrosomes during S and G2 phases of the cell cycle. The centrosomal localization was mediated by Cdc6 amino acid residues 311-366, which are conserved within other Cdc6 homologues and contains a putative nuclear export signal. Deletions or substitutions of the amino acid residues did not allow the proteins to localize to centrosomes. In contrast, DsRed tag fused to the amino acid residues localized to centrosomes. These results indicated that a centrosome localization signal is contained within amino acid residues 311-366. The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 456, Issue 3, 16 January 2015, Pages 763-767
Journal: Biochemical and Biophysical Research Communications - Volume 456, Issue 3, 16 January 2015, Pages 763-767
نویسندگان
Gwang Su Kim, Jeeheon Kang, Sung Woong Bang, Deog Su Hwang,