کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10752884 | 1050333 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AP-57/C10orf99 is a new type of mutifunctional antimicrobial peptide
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کلمات کلیدی
SCCIDCBCCDefensinsAMPsHD5HCC - HCCTAT - تاتAntimicrobial proteins - پروتئین های ضد میکروبیAntibacterial peptide - پپتید ضد باکتریAntimicrobial peptides - پپتیدهای پادمیکرب یا آنتیمایکروبیال پپتایدBasal cell carcinoma - کارسینوم سلول بازالSquamous cell carcinoma - کارسینوم سلول سنگفرشیInvasive ductal carcinoma - کارسینوم مجرای تهاجمیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AP-57/C10orf99 is a new type of mutifunctional antimicrobial peptide AP-57/C10orf99 is a new type of mutifunctional antimicrobial peptide](/preview/png/10752884.png)
چکیده انگلیسی
Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune response that provides host defence at skin and mucosal surfaces. Here, we report the identification and characterization of a new type human AMPs, termed AP-57 (Antimicrobial Peptide with 57 amino acid residues), which is also known as C10orf99 (chromosome 10 open reading frame 99). AP-57 is a short basic amphiphilic peptide with four cysteines and a net charge +14 (MW = 6.52, PI = 11.28). The highest expression of AP-57 were detected in the mucosa of stomach and colon through immunohistochemical assay. Epithelium of skin and esophagus show obvious positive staining and strong positive staining were also observed in some tumor and/or their adjacent tissues, such as esophagus cancer, hepatocellular carcinoma, squamous cell carcinoma and invasive ductal carcinoma. AP-57 exhibited broad-spectrum antimicrobial activities against Gram-positive Staphylococcus aureus, Actinomyce, and Fungi Aspergillus niger as well as mycoplasma and lentivirus. AP-57 also exhibited DNA binding capacity and specific cytotoxic effects against human B-cell lymphoma Raji. Compared with other human AMPs, AP-57 has its distinct characteristics, including longer sequence length, four cysteines, highly cationic character, cell-specific toxicity, DNA binding and tissue-specific expressing patterns. Together, AP-57 is a new type of multifunctional AMPs worthy further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 457, Issue 3, 13 February 2015, Pages 347-352
Journal: Biochemical and Biophysical Research Communications - Volume 457, Issue 3, 13 February 2015, Pages 347-352
نویسندگان
Meijia Yang, Mei Tang, Xianjun Ma, Lijia Yang, Jiangpeng He, Xirui Peng, Gang Guo, Liangxue Zhou, Na Luo, Zhu Yuan, Aiping Tong,