کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10753014 | 1050334 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transmitochondrial mito-miceÎ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceÎ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mutator mice are associated with aging or mitochondrial diseases. Here, we provide convincing evidence that all the mice examined had musculoskeletal disorders of osteoporosis and muscle atrophy, which correspond to phenotypes prevalently observed in the elderly. However, precise investigation of musculoskeletal disorders revealed that the spectra of osteoporosis and muscle atrophy phenotypes in mtDNA mutator mice were very close to those in mito-miceÎ, but different from those of aged mice. Therefore, mtDNA mutator mice and mito-miceÎ, but not aged mice, share the spectra of musculoskeletal disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 456, Issue 4, 24 January 2015, Pages 933-937
Journal: Biochemical and Biophysical Research Communications - Volume 456, Issue 4, 24 January 2015, Pages 933-937
نویسندگان
Takayuki Mito, Hikari Ishizaki, Michiko Suzuki, Hitomi Morishima, Azusa Ota, Kaori Ishikawa, Kazuto Nakada, Akiteru Maeno, Toshihiko Shiroishi, Jun-Ichi Hayashi,