Revising angiotensinogen from phylogenetic and genetic variants perspectives

- Two novel introns are inserted in AGT from selected ray-finned fishes.
- AGT is conserved on same syntenic fragment from 500 MY.
- AGT became non-inhibitory from inhibitory serpin via RCL mutations.
- AGT has 690 variants in 1092 human genomes from 14 populations.
- 121 missense variants identified in human AGT protein with 32 deleterious mutants.