کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10756619 | 1050385 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of mIκBNS stability through PEST-mediated degradation by proteasome
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NF-κBLPSDTTPMSFCHXNLSSOCSPEST sequencenuclear localization sequence - دنباله محلی سازی هسته ایdithiothreitol - دیتیوتریتولsuppressor of cytokine signaling - سرکوب کننده سیگنالینگ سیتوکینcycloheximide - سیکلوهایسیمیدphenylmethylsulfonyl fluoride - فنیل متیل سولفونیل فلورایدlipopolysaccharide - لیپوپلی ساکاریدProteasome - پروتئازومUbiquitin - یوبیکویتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of mIκBNS stability through PEST-mediated degradation by proteasome Regulation of mIκBNS stability through PEST-mediated degradation by proteasome](/preview/png/10756619.png)
چکیده انگلیسی
Negative regulatory proteins in a cytokine signaling play a critical role in restricting unwanted excess activation of the signaling pathway. At the same time, negative regulatory proteins need to be removed rapidly from cells to respond properly to the next incoming signal. A nuclear IκB protein called IκBNS is known to inhibit a subset of NF-κB target genes upon its expression by NF-κB activation. Here, we show a mechanism to control the stability of mIκBNS which might be important for cells to prepare the next round signaling. We found that mIκBNS is a short-lived protein of which the stability is controlled by proteasome, independent of ubiquitylation process. We identified that the N-terminal PEST sequence in mIκBNS was critical for the regulation of stability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 443, Issue 4, 24 January 2014, Pages 1291-1295
Journal: Biochemical and Biophysical Research Communications - Volume 443, Issue 4, 24 January 2014, Pages 1291-1295
نویسندگان
Koog Chan Park, Jiyeong Jeong, Keun Il Kim,