کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10758671 | 1050410 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met
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کلمات کلیدی
FBSPPPHGFPKM2LDHA6PGD6-phosphogluconate dehydrogenase - 6-فسفوگلاوکونات دهیدروژناز6-phosphogluconate - 6-فسفوگلوکوناتc-Met - c-metfetal bovine serum - سرم جنین گاوhuman hepatocyte growth factor - عامل رشد هپاتوسیت انسانLactate dehydrogenase A - لاکتات دهیدروژناز AGlucose metabolism - متابولیسم گلوکزpentose phosphate pathway - مسیر پنتوز فسفاتMigration - مهاجرتPyruvate kinase M2 - پیروات کیناز M2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
6-Phosphogluconate dehydrogenase (6PGD) is the third enzyme in the oxidative pentose phosphate pathway (PPP). Recently, we reported that knockdown of 6PGD inhibited lung tumor growth in vitro and in a xenograft model in mice. In this study, we continued to examine the functional role of 6PGD in cancer. We show that 6PGD expression positively correlates with advancing stage of lung carcinoma. In search of functional signals related to 6PGD, we discovered that knockdown of 6PGD significantly inhibited phosphorylation of c-Met at tyrosine residues known to be critical for activity. This downregulation of c-Met phosphorylation correlated with inhibition of cell migration in vitro. Overexpression of a constitutively active c-Met specifically rescued the migration but not proliferation phenotype of 6PGD knockdown. Therefore, 6PGD appears to be required for efficient c-Met signaling and migration of tumor cells in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 2, 20 September 2013, Pages 247-251
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 2, 20 September 2013, Pages 247-251
نویسندگان
Barden Chan, Paul A. VanderLaan, Vikas P. Sukhatme,