Keywords: gck; glucokinase; pfkm; phosphofructokinase (muscle); pfkl; phosphofructokinase (liver); pkm; pyruvate kinase (muscle); pklr; pyruvate kinase (liver and red blood cell); pck; phosphoenol pyruvate carboxykinases (cytosolic pck1 and mitochondrial pck2); fbp
مقالات ISI (ترجمه نشده)
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Keywords: Runx2; Runt-related transcription factor-2; Osx; Oster; Alp; alkaline phosphatase; Col1a1; collagen type I alpha 1; Atf4; activating transcription factor 4; LDHA; lactate dehydrogenase A; PDK1; pyruvate dehydrogenase kinase 1; TCA; tricarboxylic acid; FND
Keywords: ACTB; actin beta; ALAS1; aminoerulinate, delta-synthase 1; B2M; beta-2-microglobulin; DMEM; Dulbecco's modified Eagle's medium; DMOG; dimethyloxalylglycine; DSCR1; Down syndrome critical region gene 1; FBS; fetal bovine serum; G6PD; glucose-6-phophate deh
Keywords: AFP; alpha fetoprotein; Akt; serine/threonrine kinase; ALT; alanine aminotransferase; apoAâ
; apolipoprotein Aâ
; AST; aspartate transaminase; CPT1; carnitine palmitoyltransferase 1; FASN; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehydroge
Keywords: ARE; Antioxidant Response Element; BSO; Buthionine-S,R-Sulfoximine; CPR; Cytochrome P450 reductase; DCPIP; Dichlorophenolindophenol; GPX4; Glutathione Peroxidase 4; LDHA; Lactate dehydrogenase A; LOO; Lipid peroxide; MDA; Malonyldialdehyde; NQO1; NAD(P)H:
Keywords: ACLY; ATP citrate lyase; AKT; protein kinase B; ATP; adenosine triphosphate; ANT; adenine nucleotide translocator; AMPK; AMP-activated protein kinase; COX; cytochrome c oxidase; EGFR; epidermal growth factor receptor; ERRα; estrogen-related receptor alph
Keywords: ABR; auditory brainstem response; AC; auditory cortex; AGS; audiogenic seizure; GABR-α6; GABAAR alpha 6 subunit; GABR-δ; GABAAR delta subunit; HPRT-1; hypoxanthine phosphoribosyltransferase 1; IC; inferior colliculus; Ldha; lactate dehydrogenase A; Rpl1
Keywords: ABCA1; ATP binding cassette transporter A1; Actb; beta-actin; ApoA-I; apolipoprotein A-I; B2m; beta-2 microglobulin; Cyp2E1; cytochrome P450 2E1; FXR; farnesoid X receptor; Gapdh; glyceraldehyde-3-phosphate dehydrogenase; GLUT1; glucose transporter 1; HDL
Keywords: 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr
Keywords: PM; postmortem; PSE meat; pale, soft, and exudative meat; LC-MS/MS; liquid chromatography tandem mass spectrometry; TiSH; titanium dioxide (TiO2)-sequential elution from immobilized metal affinity chromatography (SIMAC)-hydrophilic interaction liqui
Keywords: LDHA; AMPK; Breast cancer; Prognosis; Tumor metabolism
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
Silybin counteracts doxorubicin resistance by inhibiting GLUT1 expression
Keywords: Silybin; Cancer chemosensitization; Doxorubicin; Drug resistance; GLUTs; glucose transporters; OXPHOS; oxidative phosphorylation; PFKM; 6-phosphofructokinase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; PGK1; phosphoglycerate kinase 1; LDHA; L-lactat
miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA
Keywords: miR-142-3p; Hepatocellular carcinoma; Aerobic glycolysis; Proliferation; LDHA;
Exertional myalgia, contractures and annular erythema in a patient with muscle lactate dehydrogenase (LDH) deficiency
Keywords: Glycogenosis type XI; LDHA; Erythema;
Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation
Keywords: Persister; ldhA; Escherichia coli; Single cell; Microfluidic device; Stochastic expression; Energy metabolism; Proton motive force;
Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress
Keywords: α-F1 and β-F1; Alpha and beta subunits of the ATP synthase; ACO1; Aconitase 1; CORE II; Ubiquinol-cytochrome c reductase complex; CPT1; Carnitine palmitoyltransferase I; CS; Citrate synthase; ENO 1; Enolase 1; G6PDH; Glucose-6-phosphate dehydrogenase; G
Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
Keywords: MMP-2; matrix metalloproteinase 2; VEGF; vascular endothelial growth factor; PKM2; Pyruvate kinase M2; GLUT1; Glucose transporter1; LDHA; Lactate dehydrogenase A; Quercetin; Breast Cancer; Glycolysis; Autophagy; Akt-mTOR pathway;
MiR-564 is down-regulated in osteosarcoma and inhibits the proliferation of osteosarcoma cells via targeting Akt
Keywords: OS; osteosarcoma; GLUT1; glucose transporter 1; HK2; hexokinase 2; PKM2; pyruvate kinase M2 isoform; LDHA; lactate dehydrogenase A; DMEM; Dulbeco's modified Eagle's medium; FBS; fetal bovine serum; qRT-PCR; quantitative real time-polymerase chain reaction
IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease
Keywords: Asthma; house dust mite; glycolysis; IL-1; inhibitor of κB kinase ε; lactate; lactate dehydrogenase A; AHR; Airways hyperresponsiveness; BAL; Bronchoalveolar lavage; BMI; Body mass index; DC; Dendritic cell; 2-DG; 2-Deoxyglucose; ECAR; Extracellular aci
α-cyano-4-hydroxycinnamate impairs pancreatic cancer cells by stimulating the p38 signaling pathway
Keywords: CHC; α-cyano-4-hydroxycinnamate; ERK1/2; extracellular signal-regulated kinases 1 and 2; FCS; fetal calf serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GCK3; glucokinase 3; HK1; hexokinase type 1; LDHA; lactate dehydrogenase A; MCT; monocarboxyl
Multi-step splicing of sphingomyelin synthase linear and circular RNAs
Keywords: bp; base pair(s); DNase; deoxyribonuclease; dNTP; deoxyribonucleoside triphosphate; cDNA; DNA complementary to RNA; circRNA; circular RNA; Ct; threshold cycle; GAPDH; glyceraldehyde 3-phosphate dehydrogenase gene; kb; kilobase(s) or 1000â¯bp; LDHA; lacta
The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis
Keywords: Anti-proliferative agents; Nuclear LDHA inhibition; Histone 2B gene transcription inhibitors; Oxamic acid; GSK 2837808A; FBS; foetal calf serum; LDHA; lactate dehydrogenase A; H2B; histone 2B; OXA; oxamic acid; GSKA; GSK 2837808A;
Positron emission tomography-computed tomography and 4-hydroxynonenal-histidine immunohistochemistry reveal differential onset of lipid peroxidation in primary lung cancer and in pulmonary metastasis of remote malignancies
Keywords: PET-CT; Positron Emission Tomography-Computed Tomography; 4-HNE; 4-hydroxynonenal; 18F-FDG; 18-fluorodeoxyglucose; SPN; solitary pulmonary nodule; LDHA; Lactate dehydrogenase A; SUV; standardized uptake value; ROS; reactive oxygen species; RNS; reactive n
Blocking LDHA glycolytic pathway sensitizes glioblastoma cells to radiation and temozolomide
Keywords: Glioblastoma; Radiotherapy; Temozolomide; LDHA; Oxamate; 2DG;
miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway
Keywords: ESCC; esophageal squamous cell carcinoma; miRNA; microRNA; MYCBP; MYC binding protein; UTR; untranslated-region; COSMIC; the catalogue of somatic mutation in cancer; siRNA; small interfering RNA; CCND1; cyclin D1; CDK4; cyclin-dependent kinase 4; MTA1; me
Original ArticlemiR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect
Keywords: miR-30a-5p; LDHA; Breast cancer; Aerobic glycolysis; Tumor growth;
Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma
Keywords: ccRCC; clear cell renal cell carcinoma; PDZK1; PDZ domain containing 1; CAP70; cystic fibrosis transmembrane conductance regulator associated protein of 70Â kDa; DEPs; differentially expressed proteins; GO; gene ontology; KEGG; Kyoto Encyclopedia of Genes
SOX4 Promotes Proliferative Signals by Regulating Glycolysis through AKT Activation in Melanoma Cells
Keywords: AKT; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; GLUT1; glucose transporter type 1; HK2; hexokinase 2; LDHA; lactate dehydrogenase A; MITF; micropthalmia-associated transcripti
Gen-27, a newly synthesized flavonoid, inhibits glycolysis and induces cell apoptosis via suppression of hexokinase II in human breast cancer cells
Keywords: BCA; bicinchoninic acid; Cyt c; cytochrome c; DAPI; 4â²,6-diamidino-2-phenylindole; DCFH/DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; FBS; Fetal bovine serum; HKII; hexokinase II; LDHA; lactate dehydrogenase; MMP; mitochon
1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression
Keywords: 1,25(OH)2D3; 1,25-Dihydroxyvitamin D3; 2DG; 2-Deoxyglucose; ACACA; Acetyl CoA carboxylase A; ACC; Acetyl CoA carboxylase; ACLY; ATP citrate lyase; AMPK; AMP-activated protein kinase; AR; Androgen receptor; CAMKK; Ca2Â +-calmodulin-dependent kinase kinase;
Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma
Keywords: LDHA; Cell proliferation; Cell invasion; ECAR; Warburg effect; Osteosarcoma
In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder
Keywords: βF1; ATP synthase, F1 complex, beta polypeptide; BNP; brain natriuretic peptide; C-III; complex III; COX-II; cytochrome c oxidase subunit II; COX-IV; cytochrome c oxidase subunit IV; DAPI; 4â²,6-diamidino-2-phenylindole; DHE; dihydroethidium; GPx1; glut
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells
Keywords: NOX4; NADPH oxidase 4; PPP; pentose phosphate pathway; NSCLC; non-small cell lung cancer; ROS; reactive oxygen species; OXPHOX; oxidative phosphorylation; Glut1; glucose transporter 1; LDHA; lactate dehydrogenase A; PKM2; pyruvate kinase M2; Gln; glutamin
Role of HIF-1α in the hypoxia inducible expression of the thiamine transporter, SLC19A3
Keywords: HIF-1α; hypoxia inducible factor 1 α; THTR1; thiamine transporter 1; THTR2; thiamine transporter 2; HIF-1β; hypoxia inducible factor 1 β; FBS; fetal bovine serum; DFO; deferoxamine mesylate; HRE; hypoxia responsive element; WCL; whole cell lysates; PB
ANXA1Ac2-26 peptide reduces ID1 expression in cervical carcinoma cultures
Keywords: [LaCit2]3; lanthanum citrate complex; μg; microgram; ACTB; beta-actin; ANX; annexin; ANXA1; annexin A1; BMP4; bone morphogenetic protein 4; BMPR1B; bone morphogenetic protein receptor, type IB; cDNA; complementary DNA; CO2; carbon dioxide; DNA; deoxyribo
ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2
Keywords: ECM1; PKM2; Warburg effect; GLUT1; LDHA;
A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression
Keywords: α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; DMSO; dimethyl sulfoxide; EGFP; enhanced green fluorescence protein; EPAS1; endothelial PAS domain-containing protein 1 (known as HIF-2α); EPO; erythropoietin; esiRNA; endoribonuclease-prepared
The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis
Keywords: DR; drug resistance; DDP; cisplatin; Trx-1; thioredoxin-1; ROS; reactive oxygen species; HIF-1α; hypoxia-inducible factor-1α; HKII; hexokinase II; LDHA; lactate dehydrogenase A; PDHK1; pyruvate dehydrogenase kinase 1; SCO2; cytochrome c oxidase assembly
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase
Keywords: LDHA; X-ray crystal structure; Tumor metabolism;
Hypoxia and hypoxia mimetic cooperate to counteract tumor cell resistance to glucose starvation preferentially in tumor cells with mutant p53
Keywords: mutant p53 R175H; mutant p53 Arg 175His; wt; wild type; PARP; poly(ADP-ribose) polymerase; ROS; reactive oxygen species; Superoxide dismutase; LDHA; p53 Mutation; p53 siRNA; Hypoxia; Oxidative stress;
MicroRNAs as regulators of mitochondrial function: Role in cancer suppression
Keywords: ACL; ATP citrate lyase; AGO; Argonaut; ARL2; ADP-ribosylation factor-like 2; BH3; Bcl-2 homology-3; CAT; catalase; COX IV; cytochrome c oxidase IV; CI; complex I; CII; complex II; CIV; complex IV; CPT; camptothecin; DGCR8; DiGeorge syndrome critical regio
PARP and other prospective targets for poisoning cancer cell metabolism
Keywords: ATP; adenosine 5â²-triphosphate; 3-BrPA; 3-bromopyruvate; EGFR; epidermal growth factor receptor; FDA; food and drug administration; GSH; glutathione; GSSG; oxidized GSH; GST; glutathione S-transferase; HDAC; histone deacetylase; HIF1; hypoxia inducible
6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met
Keywords: 6PGD; 6-phosphogluconate; PPP; pentose phosphate pathway; PKM2; pyruvate kinase M2; LDHA; lactate dehydrogenase A; FBS; fetal bovine serum; HGF; human hepatocyte growth factor; 6-Phosphogluconate dehydrogenase; Glucose metabolism; Glycolytic tumors; c-Met
The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients
Keywords: HIF-1; Hypoxia inducible factor-1; VEGF; vascular endothelial growth factor; MDD; major depressive disorder; BPD; bipolar disorder; BDNF; brain-derived neurotrophic factor; GDNF; glial cell line-derived neurotrophic factor; EPO; erythropoietin; GLUT1,3; g
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo
Keywords: AA; arachidonic acid; ALT; alanine aminotransferase; BSO; l-buthionine sulfoximine; CYP2E1; cytochrome P450 2E1; GSH; reduced glutathione; HE; hematoxylin-eosin; 4-HNE; 4-hydroxynonenal; HIF; hypoxia-inducible factor; HPH-2; HIF prolyl hydroxylase 2; IH
Genetically switched d-lactate production in Escherichia coli
Keywords: Genetic switch; Thermo-regulation; d-Lactate production; Lambda pL and pR tandem promoters; LdhA
A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism
Keywords: LDHA; LDHB; LDH; Glyoxylate reductase; Kinetics; Glyoxylate;
Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1
Keywords: HIF-1; hypoxia-inducible factor 1; HRE; hypoxia response element; VEGF; vascular endothelial growth factor; ENO1; enolase 1; LDHA; lactate dehydrogenase A; PGK1; phosphoglycerate kinase 1; pVHL; Von Hippel Lindau protein; LTR; long terminal repeat; SIN; s