کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649160 | 1587882 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SOX4 Promotes Proliferative Signals by Regulating Glycolysis through AKT Activation in Melanoma Cells
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کلمات کلیدی
acutely transforming retrovirus AKT8 in rodent T-cell lymphomapyruvate kinase M2 isoformeukaryotic initiation factor 4E-binding protein 1quantitative real-time reverse transcriptase-PCRLDHAHK2PKM2PGC1αSOX4MITF4E-BP1GLUT1p70S6KqRT-PCRshRNAPI3Kp70 ribosomal S6 kinase - P6O سینوسی سدیم ریبوزومیSmall interfering RNA - RNA تداخل کوچکshort hairpin RNA - RNA موی سر کوتاهsiRNA - siRNAAkt - آکتphosphatidylinositol-3-kinase - فسفاتیدیلینواستیل-3-کینازLactate dehydrogenase A - لاکتات دهیدروژناز AGlucose transporter Type 1 - نوع گلوکز 1 نوعhexokinase 2 - هگزوکیناز 2
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The sex-determining region Y-related high-mobility group box transcription factor 4 (SOX4) plays a fundamental role during embryogenesis and controls cell fate and differentiation. Recently, increased SOX4 expression has been reported in various cancer types, contributing to the progression and survival of cancer cells. However, the distinct functions and downstream targets of SOX4 remain to be fully elucidated. In this study, we initially found elevated SOX4 expression in melanoma. SOX4 regulates apoptosis and cell cycle arrest, affects glucose consumption and lactate production, and consequently, promotes melanoma cell proliferation. Moreover, we found that SOX4 rewires glucose metabolism by regulating the expression of glucose transporter type 1, hexokinase 2, and lactate dehydrogenase A at the transcriptional level. Mechanistically, SOX4 knockdown reduced activation of acutely transforming retrovirus AKT8 in rodent T-cell lymphoma and mTORC1, leading to an attenuated malignant phenotype. We also identified p70 ribosomal S6 kinase and eukaryotic initiation factor 4E-binding protein 1 as key substrates involved in the regulation of mTORC1 in melanoma cells. In conclusion, our study demonstrates the essential role of SOX4 in melanoma glycolytic metabolism through the acutely transforming retrovirus AKT8 in rodent T-cell lymphoma signaling pathway and highlights its potential as a therapeutic target in melanoma management.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 11, November 2017, Pages 2407-2416
Journal: Journal of Investigative Dermatology - Volume 137, Issue 11, November 2017, Pages 2407-2416
نویسندگان
Wei Dai, Xinyuan Xu, Shuli Li, Jingjing Ma, Qiong Shi, Sen Guo, Lin Liu, Weinan Guo, Peng Xu, Yuanmin He, Guannan Zhu, Liwen Wang, Rui Ge, Yu Liu, Zhe Jian, Gang Wang, Lan Shen, Tianwen Gao, Chunying Li,