کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10759633 1050429 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
1H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
1H NMR-based spectroscopy detects metabolic alterations in serum of patients with early-stage ulcerative colitis
چکیده انگلیسی
Ulcerative colitis (UC) has seriously impaired the health of citizens. Accurate diagnosis of UC at an early stage is crucial to improve the efficiency of treatment and prognosis. In this study, proton nuclear magnetic resonance (1H NMR)-based metabolomic analysis was performed on serum samples collected from active UC patients (n = 20) and healthy controls (n = 19), respectively. The obtained spectral profiles were subjected to multivariate data analysis. Our results showed that consistent metabolic alterations were present between the two groups. Compared to healthy controls, UC patients displayed increased 3-hydroxybutyrate, β-glucose, α-glucose, and phenylalanine, but decreased lipid in serum. These findings highlight the possibilities of NMR-based metabolomics as a non-invasive diagnostic tool for UC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 433, Issue 4, 19 April 2013, Pages 547-551
نویسندگان
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