Antiproliferative effects of phenylaminonaphthoquinones are increased by ascorbate and associated with the appearance of a senescent phenotype in human bladder cancer cells

- Phenylaminonaphthoquinones are redox cyclers able to form ROS.
- Phenylaminonaphthoquinones plus ascorbate inhibit T24 cell growth.
- Phenylaminonaphthoquinones plus ascorbate lead to necrotic-like cell death.
- Phenylaminonaphthoquinones plus ascorbate impair cell cycle and affect MAPKs.
- Phenylaminonaphthoquinones plus ascorbate induce a senescent cancer cell phenotype.