کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10759652 1050429 2013 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulation of calcium signalling by the endoplasmic reticulum in Carassius neurons
ترجمه فارسی عنوان
مدولاسیون سیگنالینگ کلسیم توسط سلول اندوپلاسمی در نورونهای کارسیوس
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
It is known that endoplasmic reticulum (ER), being a calcium store participates in the regulation of intracellular calcium concentration. Ca-ATPase of the ER is one of the crucial agents providing the calcium-accumulating function of this intracellular structure. We studied the role of the ER in modulation of calcium signalling in Carassius neurons using a Ca2+-imaging technique. We tested the role of the ER in the maintenance of a steady state calcium level in the cytoplasm and in modulation of Ca2+ transients evoked by cell depolarizations. The ER calcium stores were depleted using inhibitors of ER Ca-ATPase, which provided blocking of Ca2+ uptake by the ER. Our experiments firstly showed that the ER can significantly modulate the characteristics of intracellular calcium signals in Carassius neurons during their activity. These findings also indicate that the ER modulates the shape of Ca2+ signals rather than the basal level of intracellular Ca2+ in these neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 433, Issue 4, 19 April 2013, Pages 591-594
نویسندگان
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