Doxycycline can stimulate cytoprotection in neural stem cells with oxygen-glucose deprivation-reoxygenation injury: A potential approach to enhance effectiveness of cell transplantation therapy

► Doxycycline preconditioning reduced NSC cell death after OGD injury. ► Doxycycline preconditioning increased cell viability of NSC after OGD injury. ► Doxycycline preconditioning decreased superoxide anion production after OGD injury. ► Doxycycline upregulated Nrf2 mRNA and protein expression.