SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB

► Endogenous SIRT3 plays an essential role in mediating cell survival in cardiomyocytes. ► Overexpression of SIRT3 protects cells against oxidative stress-mediated cell death. ► The molecular mechanisms responsible for the protective effect of SIRT3 may involve the activity of the NF-κB pathway.