Mast cell degranulation mediates compound 48/80-induced hyperalgesia in mice

► Compound 48/80-mediated local mast cell degranulation causes pain and edema in mice. ► Pain responses are mediated by neutrophil influx and histamine signaling. ► Mast cell deficient mice lack pain responses to compound 48/80. ► Plantar mast cell reconstitution restores these thermal and mechanical pain responses.