Differential susceptibility of human primary aortic and coronary artery vascular cells to RNA interference

► Coronary artery SMC are more susceptible to RNAi than aortic SMC. ► Aortic and coronary EC are more susceptible to RNAi than corresponding SMC. ► Aortic and coronary cells show differential toxicity towards transfection reagents. ► Multimodal analysis of RNAi delivery can be performed using adherent cytometer.