Hydrogen sulfide prevents hypoxia-induced apoptosis via inhibition of an H2O2-activated calcium signaling pathway in mouse hippocampal neurons

► H2S suppresses hypoxia-induced intracellular ROS increase in neurons. ► H2S suppresses hypoxia-induced increase in cytosolic calcium. ► H2S suppresses hypoxia-induced mouse hippocampal neuronal apoptosis. ► H2S stops hypoxia-induced apoptosis via inhibiting H2O2-activated Ca2+ signaling.