Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila

► Mio is the Drosophila homolog of ChREBP. ► Mio is necessary for high sugar-induced lipogenic gene expression. ► Mio controls triglyceride storage in the fly fat body. ► Mio acts in the fat body to regulate food consumption. ► This study implicates Mio in tissue-specific regulation of metabolism and feeding.