Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds

► In this study, we evaluated the effect of Nutlin3a analogs on PARP1 degradation. ► Like Nutlin3a, Caylin2 induced PARP1 degradation in both 3T3-L1 and 3T3-F442A. ► Nutlin3a- or Caylin2-induced PARP1 degradation is reversible. ► Our results show the usability of the cis-imidazoline compounds as PARP1 inhibitors.