Cdc25A promotes cell survival by stimulating NF-κB activity through IκB-α phosphorylation and destabilization

► We examine the antiapoptotic mechanisms of Cdc25A. ► Smad7 decreases the phosphorylation of IκB-alpha at Ser-32. ► Smad7 positively regulates NF-κB activity through IκB-alpha ubiquitination.