Using a ubiquitin ligase as an unfolded protein sensor

► FBXO2 is a lectin-like ubiquitin ligase. ► FBXO2 binds only the exposed glycan core of glycoproteins. ► This core is only exposed on misfolded or denatured glycoproteins. ► Hence, FBXO2 can be used to develop an unfolded glycoprotein assay.