Extracellular acidosis accelerates bone resorption by enhancing osteoclast survival, adhesion, and migration

► Extracellular acidosis stimulates osteoclast-mediated bone resorption. Extracellular acidosis facilitates osteoclast survival, adhesion, and migration. Acidosis stimulates osteoclast survival/adhesion/migration-related signal. The RGD peptide blocks acidosis-induced osteoclast adhesion and migration.